Highway 395 is easily one of the most scenic drives in all of California, there's so much geology you'll see just by driving for a few hours along it. The highest point in the contiguous United States can be seen from it while a short drive from there will lead you to the lowest point in North America. You'll see lakes, dry lakes, desert, the snow-capped Sierras, extinct and dormant volcanoes, old mining operations, rivers, cool rock formations, waterfalls and more! Taking this drive summer months can be very hot and during winter, very cold but visiting in spring and falls can be very nice temperature wise.
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